Journal
TRENDS IN IMMUNOLOGY
Volume 24, Issue 1, Pages 36-43Publisher
ELSEVIER SCI LTD
DOI: 10.1016/S1471-4906(02)00009-1
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- CLINICAL CENTER [Z01CL002115] Funding Source: NIH RePORTER
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Classification of cytokines as pro-versus anti-inflammatory might not apply to the pleiotropic effects of interleukin-10 (IL-10). Several reports suggest that IL-10 enhances the function of natural killer cells, which leads, through pathogen destruction, to increased antigen availability. In addition, by inhibiting the maturation of antigen-presenting cells (APCs), IL-10 preserves their ability for antigen uptake while simultaneously hampering their migration to draining lymph nodes. This review suggests that this 'antigen-loading' phase might constitute an important component of the innate immune reaction to a pathogen. Additional proinflammatory stimuli might subsequently lead to maturation of 'loaded' APCs that could migrate to draining lymph nodes or recruit and activate adaptive immune effectors locally.
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