Journal
FRONTIERS IN BIOSCIENCE-LANDMARK
Volume 8, Issue -, Pages E68-E86Publisher
FRONTIERS IN BIOSCIENCE INC
DOI: 10.2741/925
Keywords
fibrosis; glomerulosclerosis; kidney; interstitial fibrosis; progressive kidney disease; review
Categories
Funding
- NIDDK NIH HHS [DK49362] Funding Source: Medline
- NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [R01DK049362, Z01DK043308, R56DK049362] Funding Source: NIH RePORTER
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Renal fibrosis causes significant morbidity and mortality as the primary acquired lesion leading to the need for dialysis or kidney transplantation. Fibrosis can occur in either the filtering or reabsorptive component of the nephron, the functional unit of the kidney. Experimental models have identified a number of factors that contribute to renal scarring, particularly derangements of physiology involved in the autoregulation of glomerular filtration. This in turn leads to replacement of normal structures with accumulated extracellular matrix (ECM). A spectrum of changes in the physiology of individual cells leads to the production of numerous peptide and non-peptide fibrogens that stimulate alterations in the balance between ECM synthesis and degradation to favor scarring. Other proteins and small molecules may have anti-fibrotic effects. Manipulation of these opposing systems holds the promise of effective treatments for chronic progressive kidney disease.
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