Journal
ADVANCED SYNTHESIS & CATALYSIS
Volume 345, Issue 1-2, Pages 261-274Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adsc.200390021
Keywords
asymmetric catalysis; asymmetric synthesis; Duloxetine; Fluoxetine; hydrogenation; P-ligands; ruthenium
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Enantioselective hydrogenation using chiral complexes between atropisomeric diphosphines and ruthenium is a powerful tool for producing chiral compounds. Using a simple and straightforward in situ catalyst preparation, the conditions were optimized using molecular hydrogen for both academic and industrial purposes. This led to the best conditions and the lowest catalytic ratio required for the pressure used. Hydrogenation of various P-keto esters was efficiently performed at atmospheric and higher pressures, leading to the use of very low catalyst-substrate ratios up to 1/20,000. Asymmetric hydrogenations were used in key-steps towards the total synthesis of corynomycolic acid, Duloxetine and Fluoxetine.
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