Journal
MULTIPLE SCLEROSIS JOURNAL
Volume 10, Issue 6, Pages 618-620Publisher
SAGE PUBLICATIONS LTD
DOI: 10.1191/1352458504ms1097oa
Keywords
association studies; autoimmune diseases; candidate genes; genetic susceptibility; multiple sclerosis; polymorphisms
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Solute carrier 11a1 (SLC11A1; formerly NRAMP1, where NRAMP stands for natural resistance-associated macrophage protein) is a proton/bivalent cation antiporter that localizes to late endosomes/lysosomes. SLC11A1 regulates macrophage functions that are of potential importance in the induction and/or maintenance of autoimmune diseases such as rheumatoid arthritis, type 1 diabetes and Crohn's disease. We investigated SLC11A1 gene as a candidate gene for genetic susceptibility to multiple sclerosis (MS) in our population. Four SLC11A1 gene polymorphisms (5' GT repeat, D543N, 1729+55del4 and 1729+271del4) were analysed in a case-control study of 195 patients with MS and 125 control subjects. We found no evidence of association between SLC11A1 polymorphisms and MS susceptibility in the Spanish population.
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