Journal
BIOFACTORS
Volume 21, Issue 1-4, Pages 251-253Publisher
IOS PRESS
DOI: 10.1002/biof.552210148
Keywords
walnuts; Juglans regia; juglandaceae; antioxidant; type 2 diabetes; C57BL-db/db mouse; 8-OHdG (8-hydroxy-2 '-deoxyguanosine)
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We examined the in vivo antioxidative effect of a polyphenol-rich walnut extract on oxidative stress in mice with type 2 diabetes. C57BL/KsJ-db/db mice were used as an accelerated oxidative animal model. The oral administration of the walnut polyphenol fraction at 200 mg/kg body weight for 4 weeks caused a significant decrease in the level of urinary 8-hydroxy-2'-deoxyguanosin, which is an in vivo marker of oxidative stress. These results imply that walnut polyphenols have both in vitro and in vivo antioxidant effects.
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