Journal
MEMORIAS DO INSTITUTO OSWALDO CRUZ
Volume 99, Issue 5, Pages 21-26Publisher
FUNDACO OSWALDO CRUZ
DOI: 10.1590/S0074-02762004000900004
Keywords
schistosomiasis; hepatic fibrosis; interleukin-5; interieukin-13
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Funding
- NIAID NIH HHS [AI-30639] Funding Source: Medline
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [P50AI030639] Funding Source: NIH RePORTER
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This study objective was to evaluate the cytokines associated with early events of hepatic fibrosis in schistosomiasis mansoni. Hepatic fibrosis was classified by ultrasonography in 94 patients. Immunological evaluation was performed by measurement of secreted cytokines (interleukin IL-5, IL-10, IL-13, interferon-gamma tumor necrosis factor-alpha and transforming growth factors-beta) in peripherl blood mononuclear cells stimulated by Schistosoma mansoni antigens. Significantly, higher levels of IL-5, IL-10 and IL-13 were found in supernatants of SEA-stimulated PBMC from subjects with degree III hepatic fibrosis as compared to patients with degree I or II fibrosis, Significant increases in IL-5 and IL-13 levels were also observed in some of the subjects who remained untreated for one year following initial assessment and developed more serious fibrosis during this period. The data suggests a role for type 2 cytokines in early stages of hepatic fibrosis in human schistosomiasis mansoni.
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