Journal
NEUROPSYCHOLOGIA
Volume 42, Issue 13, Pages 1858-1863Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neuropsychologia.2004.03.012
Keywords
memory; learning; striatum; Parkinson's disease; Alzheimer's disease; progressive supranuclear palsy
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We investigated the acquisition and long-term retention of new skills in patients with cortical (Alzheimer's disease, AD) and subcortical (progressive supranuclear palsy, PSP; Parkinson's disease, PD) degeneration. The motor skill task performance of the PD and PSP patients improved with training, but the improvement disappeared within a few months, whereas AD patients retained learned skills for 3-18 months. The results of our experiments show that subcortical dysfunction induces a retention deficit for newly learned motor skills. Our present study suggests that a normal striatum is necessary for the formation of long-lasting motor skills, and that the striatum plays an important role as a motor skill consolidation system. (C) 2004 Elsevier Ltd. All rights reserved.
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