Journal
NUCLEAR MEDICINE COMMUNICATIONS
Volume 25, Issue 1, Pages 67-74Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/00006231-200401000-00010
Keywords
single photon emission computed tomography; Tc-99m ethyl cysteinate dimer; regional cerebral blood flow; normal database
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To make it possible to share a normal database in single photon emission computed tomography (SPECT) studies, we developed a new method for converting a SPECT image in one physical condition to that in another condition for data acquisition and reconstruction. A Hoffman 3-dimensional brain phantom experiment was conducted to determine systematic differences between collimators and reconstruction processes. SPECT images for the brain phantom were obtained using fan-beam collimators with scatter and attenuation corrections and using parallel-hole collimators without any correction. Dividing these two phantom images after anatomical standardization by Statistical Parametric Mapping 99 (SPM99) created a 3-dimensional conversion map. This conversion map was applied to convert an anatomically standardized SPECT image using parallel-hole collimators without any correction to that using fan-beam collimators with scatter and attenuation corrections in eleven subjects who underwent sequential SPECT measurements using different collimators after injection of Tc-99m ethyl cysteinate dimer. The SPM99 demonstrated adequate validity of this conversion in comparative analyses of these sequential SPECT images with different collimators. This may be a promising approach for further sharing of a normal database in SPECT imaging between different cameras. ((C) 2004 Lippincott Williams Wilkins).
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