Journal
LUPUS
Volume 13, Issue 3, Pages 165-167Publisher
SAGE PUBLICATIONS LTD
DOI: 10.1191/0961203304lu523oa
Keywords
gene polymorphism; membranous glomerulonephritis (WHO class V); MCP-1; proliferative glomerulonephritis (WHO class IV); SLE
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Lupus nephritis presents two polar histological patterns, diffuse proliferative glomerulonephritis (DPGN) and membranous glomerulonephritis (MGN). In the kidney tissue of DPGN, numerous mononuclear cells were seen in the interstitium and glomeruli; on the other hand in MGN, infiltrating cells were less frequent. Monocyte chemoattractant protein-1 (MCP-1) is a potent chemoattractant for monocytes, T-cells, and natural killer cells. In this study we assessed the significance of the MCP-1 gene in determination of the histological phenotype in lupus nephritis. There was no association between the risk of DPGN and the MCP-1 gene genotype.
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