Journal
INTERNATIONAL IMMUNOLOGY
Volume 16, Issue 1, Pages 149-161Publisher
OXFORD UNIV PRESS
DOI: 10.1093/intimm/dxh012
Keywords
Candida albicans; dendritic cell; dimorphism; receptor; T-h
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Dendritic cells (DC) sense saprophytic yeast and pathogenic, filamentous forms of Candida albicans in a specific way, resulting in disparate patterns of DC and T-h cell activation. Using human and murine DC, such disparate patterns could be traced to the exploitation of distinct recognition receptors. Although usage of mannose receptors led to protective type 1 responses in mice, entry through Fcgamma receptors was responsible for suppression of mannose receptor-dependent reactivity, onset of type 2 responses and associated pathology. As the usage of distinct receptors selectively occurred with yeast or hyphal forms of the fungus, these findings suggest that the responsibility for pathogenicity of C. albicans is shared by the organism and DC, with implications for fungal virulence, immunity and vaccine development.
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