Journal
CELL BIOCHEMISTRY AND BIOPHYSICS
Volume 40, Issue 2, Pages 185-206Publisher
HUMANA PRESS INC
DOI: 10.1385/CBB:40:2:185
Keywords
V-ATPase; F-ATPase; organelle; plasma membrane; tumor; invasion; metastasis; apoptosis
Funding
- PHS HHS [R01-65695] Funding Source: Medline
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Vacuolar-type H+-adenosine triphosphatase (V-ATPase) is one of the most fundamental enzymes in nature. V ATPases are responsible for the regulation of proton concentration in the intracellular acidic compartments. It has similar structure with the mitochondrial F0F1-ATP synthase (F-ATPase).dagger The V ATPases are composed of multiple subunits and have various physiological functions, including membrane and organelle protein sorting, neurotransmitter uptake, cellular degradative processes, and cytosolic pH regulation. The V-ATPases have been involved in multidrug resistance. Recently, plasma membrane V-ATPases have been involved in regulation of extracellular acidity, essential for cellular invasiveness and proliferation in tumor metastasis. The current knowledge regarding the structure and function of V ATPase and its role in cancer biology is discussed.
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