Journal
DEMENTIA AND GERIATRIC COGNITIVE DISORDERS
Volume 17, Issue 4, Pages 307-310Publisher
KARGER
DOI: 10.1159/000077160
Keywords
frontotemporal lobar degeneration; semantic dementia; progressive non-fluent aphasia; frontotemporal dementia; longitudinal; volumetric MRI
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Funding
- Medical Research Council [G116/143] Funding Source: Medline
- MRC [G116/143] Funding Source: UKRI
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The aim of this study was to assess the longitudinal patterns of regional change in the different syndromic variants of frontotemporal lobar degeneration (FTLD). Ten patients with semantic dementia, 7 with progressive nonfluent aphasia and 29 with frontotemporal dementia had two serial volumetric MR scans. Fluid registration was used to match serial scans from each individual. Voxel-level analysis of change across subject groups was performed using statistical parametric mapping. The analysis showed patterns of increased rates of volume loss ( atrophy) in frontal, temporal and parietal regions in the whole FTLD group compared with controls. The different FTLD syndromes displayed different patterns of change. This technique gives an insight into disease evolution over time in these disorders and may be useful as a method of tracking change in clinical trials. Copyright (C) 2004 S. Karger AG, Basel.
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