Journal
ORGANIC PROCESS RESEARCH & DEVELOPMENT
Volume 8, Issue 1, Pages 18-21Publisher
AMER CHEMICAL SOC
DOI: 10.1021/op0341263
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An environmentally benign and efficient process for the preparation of beta-hydroxyl ketones was developed by the practical cross-aldol reactions of 2-acetylpyridine, acetophenone, and cyclohexanone with 4-nitro-, 3-nitro-, and 2-nitrobenzaldehydes in water catalyzed by Na2CO3 in very high yields.
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