Journal
BLOOD PURIFICATION
Volume 22, Issue 5, Pages 440-445Publisher
KARGER
DOI: 10.1159/000080790
Keywords
chronic renal injury reversal; renal replacement therapy; renin-angiotensin system; transforming growth factor-beta(1); bone morphogenic protein-7; hepatocyte growth factor
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Funding
- NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [R01DK062987] Funding Source: NIH RePORTER
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Progression of chronic nephropathies still represents a major challenge for clinical nephrologists. Specific therapies that prevent patients from requiring dialysis or transplantation are still not available. However, recent experimental studies have demonstrated that regression of advanced lesions in the kidney can be achieved. This review summarizes the recent therapeutic advances using experimental models that might translate into novel human therapies to prevent, or significantly delay, requirement of renal replacement therapy. Copyright (C) 2004 S. Karger AG, Basel.
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