Journal
LUPUS
Volume 13, Issue 3, Pages 192-200Publisher
SAGE PUBLICATIONS LTD
DOI: 10.1191/0961203303lu1002oa
Keywords
CD4(+)CD25(+) T cells; histone peptide; nasal tolerance; spontaneous lupus
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It has been repeatedly shown that a subset of CD4(+) T cells that constitutively express CD25 on their surface plays a role in the maintenance of self-tolerance. They may directly or indirectly affect the development of autoimmunity in susceptible mice and humans. In this study, we examine the relationship between the percentage of peripheral CD4(+) CD25(+) T cells and the state of disease in spontaneous models of autoimmune disease. We found that both BWF1 and SNF1 mice that spontaneously develop a lupus-like disease have inherently lower percentage of the CD4(+) CD25(+) T cells in their CD4 repertoire compared with normal Balb/c and DBA/1 mice. The percentage of CD4(+) CD25(+) T cells was found to be increased in both normal and lupus-pronemice as they reached 7 to 8 months of age. However, mice with an autoimmune background differed from mice on a normal background in that the number of CD4(+) CD25(+) T cells never reached 5% of the CD4 population. The lower number of the CD4(+) CD25(+) T cells in autoimmune mice was restored to the level seen in normal mice following administration of histone peptide H471 or OVA((323-339)) peptide in the absence of adjuvant intranasally but not intradermally. As such transmucosal treatment may ameliorate disease, we conclude that a deficiency in the CD4(+)CD25(+) T cell pool contributes to a susceptibility to develop spontaneous lupus disease.
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