Journal
MICROBIOLOGY AND IMMUNOLOGY
Volume 48, Issue 12, Pages 971-975Publisher
WILEY
DOI: 10.1111/j.1348-0421.2004.tb03627.x
Keywords
com1 gene; Coxiella burnetii; icd gene; PCR-RFLP
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The genetic variation of Japanese isolates of Coxiella burnetii, the agent of Q fever, was found for the first time. Forty-nine out of 72 isolates had the chronic pattern of the isocitrate hydrogenase gene. Sequence analysis revealed that the isolates have a specific nucleotide sequence. The putative amino acid sequence was the same as that of chronic reference strains. These results suggest the variation of C. burnetii isolates in Japan.
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