Journal
TOXICOLOGIC PATHOLOGY
Volume 32, Issue 1, Pages 91-99Publisher
SAGE PUBLICATIONS INC
DOI: 10.1080/01926230490265902
Keywords
soy; isoflavones; phytoestrogens; mice; reproductive system
Categories
Funding
- NCI NIH HHS [CA71789] Funding Source: Medline
- NHLBI NIH HHS [R01 HL64746] Funding Source: Medline
- NATIONAL CANCER INSTITUTE [P30CA071789] Funding Source: NIH RePORTER
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [R01HL064746] Funding Source: NIH RePORTER
Ask authors/readers for more resources
We assessed the effects of dietary consumption of soy isoflavone aglycones on the reproductive tract of sexually mature male and female mice. Isoflavone concentrates with a ratio of 10:1, 2:1 or 1:10 genistein: daidzein (G:D) were added to provide 120 mg total isoflavones/1800 Calories (approximately 40 mg/kg body weight) to diets having either casein/lactalbumin or soy protein isolate as the source of protein. After 16 weeks, mice were necropsied and gross and histopathologic assessments of uterus, vagina, testes and accessory sex glands were completed. Effects of the 10G:1D isoflavone concentrates were absent or minimal in females but in males included atrophy of accessory sex glands. In contrast, the 2G:1D and 1G:10D concentrates caused dramatic estrogenic effects in both male and female mice. Effects in females included endometritis and effects typical of estrogenic stimulation (i.e., uterine enlargement, keratinization of vaginal epithelium, increased height of endometrial surface epithelial cells, and uterine squamous metaplasia). Effects in males included reduced plasma testosterone concentrations, atrophy of seminiferous epithelium, atrophy of accessory sex glands, and squamous metaplasia of seminal vesicles. Some effects varied with protein source. We conclude that a diet containing approximately 40 mg/kg soy isoflavone aglycones with a genistein: daidzein ratio of 2: 1 or less has marked estrogenic effects on the reproductive system of male and female mice.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available