Journal
CELL BIOLOGY INTERNATIONAL
Volume 28, Issue 6, Pages 483-486Publisher
WILEY
DOI: 10.1016/j.cellbi.2004.03.004
Keywords
cell culture; endothelial cells; oxidants; reactive oxygen species; nitric oxide
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Proliferation of human umbilical vein endothelial cells in vitro was inhibited by high concentrations of oxidants and nitric oxide donors but stimulated by low (micromolar or submicromolar) concentrations of hydrogen peroxide, menadione, tert-butyl hydroperoxide, AAPH, nitroglycerin, SIN-1 and sodium nitroprusside. The stimulation seems to be dependent upon generation of secondary reactive oxygen species as inferred from attenuation of cell proliferation by superoxide dismutase and catalase. These results point to another type of possible artefact of cell culture, viz. stimulation of cell proliferation by low concentrations of oxidants. (C) 2004 International Federation for Cell Biology. Published by Elsevier Ltd. All rights reserved.
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