Journal
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
Volume 15, Issue 1, Pages 25-40Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1163/156856204322752219
Keywords
tosan-gelatin-hyaluronic acid scaffold; keratinocyte; fibroblasts; co-culture; artificial skin
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Chitosan-gelatin-hyaluronic acid scaffolds for tissue regeneration were fabricated by freezing and lyophilizing methods. The scaffolds showed a higher water uptake and retention abilities than chitosan-gelatin scaffolds did. Fibroblasts cultured in chitosan-gelatin-hyaluronic acid scaffolds grew and proliferated well, and they exhibited a strong viability. Keratinocytes were co-cultured with fibroblasts in chitosan-gelatin-hyaluronic acid scaffolds to construct an artificial bilayer skin in vitro. The artificial skin obtained was flexible and had good mechanical properties. The data from this study suggested that chitosan-gelatin-hyaluronic acid scaffolds are suitable for preparing a bilayer skin substitute.
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