Journal
CHIMIA
Volume 58, Issue 3, Pages 153-155Publisher
NEW SWISS CHEMICAL SOC
DOI: 10.2533/000942904777678181
Keywords
biphasic catalysis; Friedel-Crafts alkylation; perfluorinated NH-acidic imides; alpha-tocopherol; tris(perfluoroalkylsulfonyl) methanes
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The key-step in the industrial synthesis of (all-rac)-alpha-tocopherol (synthetic vitamin E) is the condensation reaction of trimethylhydroquinone with the C-20 building block isophytol. For this Friedel-Crafts-type reaction, perfluorinated NH- and CH-acidic compounds (perfluoroalkyl(aryl)sulfonyl imides and methides) have been applied as excellent catalysts, preferably in biphasic solvent systems.
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