Journal
JOURNAL OF ORTHOPAEDIC SCIENCE
Volume 9, Issue 1, Pages 76-85Publisher
SPRINGER TOKYO
DOI: 10.1007/s00776-003-0734-7
Keywords
aging; type 2C muscle fibers; muscular atrophy
Categories
Ask authors/readers for more resources
To investigate the effects of aging on the degree of muscular atrophy caused by disuse and its recovery, we evaluated the recovery from muscular atrophy induced in both young and old rats under the same conditions. The soleus was atrophied by immobilization of the foot joint in a hindlimb and unweighting of the bilateral hindlimbs for 2 weeks, and measurement of the wet weight of muscles and biochemical examination were performed 2, 4, and 6 weeks after the removal of unweighting and fixation during the recovery period of 6 weeks. There was no difference in the degree of atrophy in the fixed soleus between the young and old rats. The recovery from atrophy was delayed in the older rats compared to the young rats. In the unfixed hindlimb, the degree of atrophy was low in both the old and young rats, and the recovery was rapid. Because the recovery from disuse muscular atrophy is delayed with aging, it is necessary to avoid unweighting and immobilization, or to reduce the period spent under such conditions.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available