Journal
MATRIX BIOLOGY
Volume 22, Issue 7, Pages 521-538Publisher
ELSEVIER
DOI: 10.1016/j.matbio.2003.10.006
Keywords
basement membrane; laminins; mutagenesis
Categories
Funding
- NIDDK NIH HHS [R37 DK036425, DK36425] Funding Source: Medline
- NINDS NIH HHS [NS40759, NS38469] Funding Source: Medline
- NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [R01DK036425, R37DK036425] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [R01NS040759, R01NS038469] Funding Source: NIH RePORTER
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Basement membranes are cell surface associated extracellular matrices containing laminins, type IV collagens, nidogens, perlecan, agrin, and other macromolecules. Biochemical and ultrastructural studies have suggested that basement membrane assembly and integrity is provided through multiple component interactions consisting of self-polymerizations, inter-component binding, and cell surface adhesions. Mutagenesis in vertebrate embryos and embryoid bodies have led to revisions of this model, providing evidence that laminins are essential for the formation of an initial polymeric scaffold of cell-attached matrix which matures in stability, ligand diversity, and functional complexity as additional matrix components are integrated into the scaffold. These studies also demonstrate that basement membrane components differentially promote cell polarization, organize and compartmentalize developing tissues, and maintain adult tissue function. (C) 2003 Elsevier B.V./International Society of Matrix Biology. All rights reserved.
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