Journal
JOURNAL OF MOLECULAR NEUROSCIENCE
Volume 23, Issue 3, Pages 157-165Publisher
HUMANA PRESS INC
DOI: 10.1385/JMN:23:3:157
Keywords
Alzheimer's disease; dementia; genetics; apolipoprotein E; Gompertz; aging; epidemiology
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The risk of developing Alzheimer's disease (AD) is tied most closely to age and appears to follow Gompertzian kinetics. However, specific genetic factors are also linked closely to AD, and the apolipoprotein E (APOE) genotype accounts for as much of 50% of the attributable risk for AD in many populations. This paper reviews the onset, diagnosis, and epidemiology of AD, specifically with regard to the APOE genotype and the interaction of the genotype with age.
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