Journal
BIOLOGY OF THE NEONATE
Volume 85, Issue 4, Pages 305-313Publisher
KARGER
DOI: 10.1159/000078175
Keywords
infant, premature; infection; inflammation; bronchopulmonary dysplasia; leukomalacia, periventricular; white matter damage; cerebral palsy
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Funding
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [K08HL004436] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [U01NS040069] Funding Source: NIH RePORTER
- NHLBI NIH HHS [HL004436] Funding Source: Medline
- NINDS NIH HHS [NS040069] Funding Source: Medline
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The relationships among bronchopulmonary dysplasia (BPD), brain white matter damage (WMD) and cerebral palsy (CP) are far from simple. Apparently, BPD and WMD are not associated, while BPD and CP are. The most likely explanation for this paradox is that ultrasound imaging does not identify all the WMD that might lead to CP ('tip-of-the-iceberg effect'). We discuss further methodological inconsistencies, etiological peculiarities related to antenatal infection/inflammation, and intervention-related issues. In particular, we expand on the multiple-hit scenario in the etiology of BPD and offer support for the hypothesis that it is not lung disease, but factors associated with lung disease ( e. g. postnatal steroid exposure) that increase the risk for developmental disability in childhood. Copyright (C) 2004 S. Karger AG, Basel.
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