Journal
SCANDINAVIAN JOURNAL OF RHEUMATOLOGY
Volume 33, Issue -, Pages 9-11Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/03009740410006952
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There is evidence from both human and animal research that 5-hydroxytryptamine(3) (5-HT3) receptor antagonists.. particularly tropisetron, exert analgesic and antiinflammatory effects. However, the underlying mechanisms of these effects including the expression of 5-HT3 receptors in cells of the immune system have not yet been investigated in detail. Therefore, we investigated the expression of the 5-HT3A receptor in primary human monocytes, chondrocytes, T-cells, dendritic cells, and synovial tissue. We found that 5-HT3A receptors are expressed in monocytes, chondrocytes, T-cells, and synovial tissue but not in dendritic cells. Our data show that 5-HT3A receptors are widely expressed in cells of the immune system and that they might play an important role in inflammatory events and in the observed antiphlogistic effects of 5-HT3 receptor antagonists.
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