Journal
MINI-REVIEWS IN MEDICINAL CHEMISTRY
Volume 4, Issue 1, Pages 41-48Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1389557043487574
Keywords
vanadyl compound; insulinomimetic activity; diabetes mellitus; blood circulation monitoring-electron paramagnetic resonance (BCM-EPR); pharmacokinetic analysis; bioavailability; enteric-coated capsule
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To treat patients suffering from diabetes mellitus, we developed several types of orally active vanadyl complexes to replace painful insulin injections, and prepared them in the form of enteric-coated capsules containing vanadium compounds. Pharmacokinetic analysis demonstrated that these capsules enhance the bioavailability of pharmacologically active vanadyl species.
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