Journal
NEUROENDOCRINOLOGY
Volume 79, Issue 1, Pages 43-53Publisher
KARGER
DOI: 10.1159/000076044
Keywords
glutamate; glutamate receptors; corticotropin; adrenal steroids; catecholamines; serotonin; paraventricular nucleus
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The effects of ionotropic glutamate receptor antagonists on the pituitary adrenal responses following injections of norepinephrine ( NE) and serotonin (5-HT) receptor agonists into the hypothalamic paraventricular nucleus (PVN) or electrical stimulation of central NE and 5-HT pathways were studied in anesthetized male rats. PVN injections of an alpha(1)-adrenergic receptor agonist or a serotonergic 5-HT1A receptor agonist markedly increased both adrenocorticotropin ( ACTH) and corticosterone ( CS) serum levels. These responses were significantly inhibited by separate pre-injection of the selective non-NMDA and NMDA glutamate receptor subtype antagonists into the PVN in a dose-dependent manner. Electrical stimulation of either the ventral noradrenergic bundle or the dorsal raphe nucleus markedly increased serum ACTH and CS. These responses were also significantly attenuated by pre-injection of the above glutamate ionotropic receptor antagonists in a dose-dependent manner. These results suggest that glutamatergic interneurons in the PVN, acting via non-NMDA and NMDA receptors, may act as an excitatory mechanism in the NE and 5-HT control of hypothalamic ACTH secretagogues. Copyright (C) 2004 S. Karger AG, Basel.
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