Journal
CELLS TISSUES ORGANS
Volume 176, Issue 1-3, Pages 67-78Publisher
KARGER
DOI: 10.1159/000075028
Keywords
NFATC2; macrophage; interleukin-4; prostaglandin F2 alpha; myotube
Funding
- NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES [R01AR047314, R01AR048884] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF DENTAL &CRANIOFACIAL RESEARCH [R01DE013040] Funding Source: NIH RePORTER
- NIAMS NIH HHS [AR-47314, AR-48884] Funding Source: Medline
- NIDCR NIH HHS [DE-13040] Funding Source: Medline
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In mammals, cell fusion occurs among a limited number of cell types: sperm and oocytes during fertilization, trophoblasts during placenta formation, macrophages during giant cell and osteoclast formation and myoblasts in the formation of myofibers and myotubes. The molecular mechanisms involved in these membrane fusion events largely are unknown. This review will focus on the known molecules that regulate myoblast fusion with an emphasis on a novel signaling pathway involving the calcium-regulated transcription factor NFATC2 in the regulation of myoblast fusion. Copyright (C) 2004 S. Karger AG, Basel.
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