Journal
EXPERIMENTAL PARASITOLOGY
Volume 106, Issue 1-2, Pages 59-61Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.exppara.2004.01.003
Keywords
Schistosoma mansoni; trematode; developmental biology; dioecy; recombination activating gene; adaptive immunity
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Funding
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [F32AI010424] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [P30DK026743] Funding Source: NIH RePORTER
- NIAID NIH HHS [F32 AI010424-03, F32 AI10424, F32 AI010424] Funding Source: Medline
- NIDDK NIH HHS [P30 DK26743, P30 DK026743] Funding Source: Medline
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Development of female schistosomes from infections cercariae to mature egg-producing adults requires both male schistosomes and an intact adaptive immune system. By examining single sex infections in immunodeficient mice, we provide evidence that female schistosome development is not directly influenced by the adaptive immune system, whereas male development is. Our data are consistent with a sequential model of schistosome development, where the adaptive immune system signals development of mature males, which subsequently stimulate development of mature females. The male schistosome therefore appears to play a central role both in transducing signals from the adaptive immune system and in facilitating female development. (C) 2004 Elsevier Inc. All rights reserved.
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