Journal
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
Volume 27, Issue 8, Pages 739-749Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neubiorev.2003.11.007
Keywords
vulnerability; dysregulation; drug dependence allostasis
Categories
Funding
- NIAAA NIH HHS [AA08459, AA06420] Funding Source: Medline
- NIDA NIH HHS [DA04043, DA04398, DA11946, DA13821, R56 DA011946, DA11004] Funding Source: Medline
- NIDDK NIH HHS [DK26741] Funding Source: Medline
- NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [P01DK026741] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM [P60AA006420, R37AA008459, R01AA008459, P50AA006420] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON DRUG ABUSE [R01DA004043, R01DA011946, R56DA011946, R01DA013821, R01DA004398, R29DA011004] Funding Source: NIH RePORTER
Ask authors/readers for more resources
Drug addiction is a chronic relapsing disorder characterized by compulsive drug intake, loss of control over intake, and impairment in social and occupational function. Animal models have been developed for various stages of the addiction cycle with a focus in our work on the motivational effects of drug dependence. A conceptual framework focused on allostatic changes in reward function that lead to excessive drug intake provides a heuristic framework with which to identify the neurobiologic mechanisms involved in the development of drug addiction. Neuropharmacologic studies in animal models have provided evidence for the dysregulation of specific neurochemical mechanisms in specific brain reward and stress circuits that provide the negative motivational state that drives addiction. The allostatic model integrates molecular, cellular and circuitry neuroadaptations in brain motivational systems produced by chronic drug ingestion with genetic vulnerability, and provides a new opportunity to translate advances in animal studies to the human condition. (C) 2003 Elsevier Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available