Journal
IMMUNOLOGIC RESEARCH
Volume 29, Issue 1-3, Pages 151-160Publisher
HUMANA PRESS INC
DOI: 10.1385/IR:29:1-3:151
Keywords
immunological memory; T-cell immunity; cytotoxic T-cells; viral immunity; CD8 T-cell differentiation
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Funding
- NIAID NIH HHS [AI 30048, AI 44644] Funding Source: Medline
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R37AI030048, R01AI030048] Funding Source: NIH RePORTER
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CD8 T cells contribute to clearance and long-term protection following acute infection with certain viruses, bacteria, and protozoa, and may play an important role in tumor immunity. Primary adaptive CD8 T-cell responses have been conceptually divided into four phases: activation, expansion, contraction, and memory. We summarize each phase of the response, and discuss recent advances in our understanding of the development and maintenance of CD8 T-cell memory.
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