Journal
TRENDS IN CARDIOVASCULAR MEDICINE
Volume 14, Issue 1, Pages 13-18Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tcm.2003.09.005
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Funding
- NHLBI NIH HHS [HL 63926] Funding Source: Medline
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [P01HL063926] Funding Source: NIH RePORTER
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This review focuses on recent studies investigating the genetic regulatory mechanisms leading to formation of morphologically, functionally, and molecularly distinct cardiac chambers. The regulation of four representative chamber-specific genes that have been studied in detail is reviewed. These genes include the atrial-specific genes, myosin light chain-2a (MLC2a), slow myosin heavy chain-3 (slow MyHC3), and atrial natriuretic factor (ANF) and the ventricular specific gene, myosin light chain-2v (MLC2v). Comparison of these promoters reveals some generalizations about the regulatory mechanisms involved in chamberspecific gene expression but, equally, indicates the large gaps in the knowledge concerning this intriguing genetic program. (C) 2004, Elsevier Inc.
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