4.2 Article

Linkage analysis of smoking initiation and quantity in Dutch sibling pairs

Journal

PHARMACOGENOMICS JOURNAL
Volume 4, Issue 4, Pages 274-282

Publisher

NATURE PUBLISHING GROUP
DOI: 10.1038/sj.tpj.6500255

Keywords

QTL; linkage; sib pairs; heritability; smoking

Funding

  1. NIDA NIH HHS [DA-11287] Funding Source: Medline
  2. NIMH NIH HHS [MH-01458] Funding Source: Medline
  3. NATIONAL INSTITUTE OF MENTAL HEALTH [K02MH001458] Funding Source: NIH RePORTER
  4. NATIONAL INSTITUTE ON DRUG ABUSE [R01DA011287] Funding Source: NIH RePORTER

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The heritability of smoking initiation ( SI) and number of cigarettes smoked (NC) was determined in 3657 Dutch twin pairs. For SI a heritability of 36% was found and for NC of 51%. Both SI and NC were also significantly influenced by environmental factors shared by family members. The etiological factors that influence these traits partly overlap. Linkage analyses were performed on data of 536 DZ twins and siblings from 192 families, forming 592 sibling pairs. Results suggested QTLs on chromosome 6 (LOD = 3.05) and chromosome 14 (LOD = 1.66) for SI and on chromosome 3 (LOD = 1.98) for NC. Strikingly, on chromosome 10 a peak was found in the same region for both SI (LOD = 1.92) and for NC (LOD = 2.29) which may partly explain the overlapping etiological factors for SI and NC.

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