Journal
CATALYSIS TODAY
Volume 140, Issue 1-2, Pages 51-57Publisher
ELSEVIER
DOI: 10.1016/j.cattod.2008.07.007
Keywords
Asymmetric catalysis; Supported catalysts; Cyclopropanation
Funding
- M.I.U.R.
- Universita di Pisa
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A new insoluble polymer-bound bisoxazoline (IPB-box) was prepared by grafting a suitable chiral ligand derivative onto a commercial Merrifield resin. The material obtained by this route was employed in the asymmetric copper-catalyzed olefin cyclopropa nation, obtaining good activity and enantioselectivity values (54-84% yield, 71-93% ee) for a range of substrates. In addition, some key factors required for the development of effective IPB-box systems are discussed, including the local ligand symmetry and the influence of immobilization technique and catalyst loading. (C) 2008 Elsevier B.V. All rights reserved.
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