Journal
IMMUNOLOGICAL INVESTIGATIONS
Volume 33, Issue 2, Pages 109-142Publisher
TAYLOR & FRANCIS INC
DOI: 10.1081/IMM-120030732
Keywords
T lymphocytes; IL-2 family; signaling pathways; regulation
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Funding
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R01AI049329, R21AI049329] Funding Source: NIH RePORTER
- NIAID NIH HHS [AI49329] Funding Source: Medline
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Lymphocyte populations in the immune system are maintained by a well-organized balance between cellular proliferation, cellular survival and programmed cell death (apoptosis). One of the primary functions of many cytokines is to coordinate these processes. In particular, the interleukin (IL)-2 family of cytokines, which consists of six cytokines (IL-2, IL-4, IL-7, IL-9, IL-15 and IL-21) that all share a common receptor subunit (gammac), plays a major role in promoting and maintaining T lymphocyte populations. The details of the molecular signaling pathways mediated by these cytokines have not been fully elucidated. However, the three major pathways clearly involved include the JAK/STAT, MAPK and phosphatidylinositol 3-kinase (PI3K) pathways. The details of these pathways as they apply to the IL-2 family of cytokines is discussed, with a focus on their roles in proliferation and survival signaling.
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