Journal
ACS CHEMICAL BIOLOGY
Volume 11, Issue 1, Pages 104-112Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acschembio.5b00537
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Funding
- Department of Science and Technology, Government of India [DST/INT/Spain/P-30/11]
- CSIR-National Institute for Interdisciplinary Science and Technology [CSC 0134, BSC 0112]
- Spanish Ministerio de Economia y Competitividad [MINECO: PRI-PIBIN-2011-1011, SAF 2012-33404]
- Instituto de Salud Carlos III [TerCel RD12/0019/0004]
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We synthesized novel tetraphenylethene (TPE) conjugates, which undergo unique self-assembly to form spherical nanoparticles that exhibited aggregation induced emission (AIE) in the near-infrared region. These nanoparticles showed significant singlet oxygen generation efficiency, negligible dark toxicity, rapid cellular uptake, efficient localization in cytoplasm, and high in vitro photocytotoxicity as well as in vivo photodynamic activity against a human prostate tumor animal model. This study demonstrates, for the first time, the power of the self-assembled AIE active tetraphenylethene conjugates in aqueous media as a nanoplatform for future therapeutic applications.
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