Journal
ANNUAL REVIEW OF MICROBIOLOGY
Volume 58, Issue -, Pages 329-363Publisher
ANNUAL REVIEWS
DOI: 10.1146/annurev.micro.58.030603.123726
Keywords
Crohn's disease; diarrhea; granulomatous enteritis; mycobacteria; ruminants
Categories
Funding
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R03AI051176] Funding Source: NIH RePORTER
- NIAID NIH HHS [5R03AI051176-02] Funding Source: Medline
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Johne's disease is a chronic diarrhea affecting all ruminants. Mycobacterium avium subsp. paratuberculosis (MAP), a slowly growing mycobacteria, is the etiologic agent. There is also a concern that MAP might be a causative agent of some cases of inflammatory bowel disease in humans, especially Crohn's disease. Food products including pasteurized bovine milk have been suggested as potential sources of human infection. This review addresses microbial factors that may contribute to its pathogenicity. In addition, the experimental evidence defining MAP as the cause of Johne's disease and the issues and controversies surrounding its potential pathogenic role in humans are discussed.
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