Journal
ANNUAL REVIEW OF NEUROSCIENCE
Volume 27, Issue -, Pages 145-167Publisher
ANNUAL REVIEWS
DOI: 10.1146/annurev.neuro.27.070203.144308
Keywords
automaticity; motor learning; locomotor rehabilitation; therapeutic strategies
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Funding
- NINDS NIH HHS [1RO1NS40917, 1RO1NS42951, 1PO1NS16333] Funding Source: Medline
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [R01NS042951, P01NS016333, R01NS040917] Funding Source: NIH RePORTER
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Motor function is severely disrupted following spinal cord injury (SCI). The spinal circuitry, however, exhibits a great degree of automaticity and plasticity after an injury. Automaticity implies that the spinal circuits have some capacity to perform complex motor tasks following the disruption of supraspinal input, and evidence for plasticity suggests that biochemical changes at the cellular level in the spinal cord can be induced in an activity-dependent manner that correlates with sensorimotor recovery. These characteristics should be strongly considered as advantageous in developing therapeutic strategies to assist in the recovery of locomotor function following SCI. Rehabilitative efforts combining locomotor training pharmacological means and/or spinal cord electrical stimulation paradigms will most likely result in more effective methods of recovery than using only one intervention.
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