Journal
ANNUAL REVIEW OF MICROBIOLOGY
Volume 58, Issue -, Pages 587-610Publisher
ANNUAL REVIEWS
DOI: 10.1146/annurev.micro.57.030502.090934
Keywords
infectious cycle; virulence factors; genomes; pathophysiology
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Listeria monocytogenes is the etiological agent of listeriosis, a severe human foodborne infection characterized by gastroenteritis, meningitis, encephalitis, abortions, and perinatal infections. This gram-positive bacterium is a facultative intracellular pathogen that induces its own uptake into nonphagocytic cells and spreads from cell to cell using an actin-based motility process. This review covers both well-established and recent advances in the characterization of L. monocytogenes virulence determinants and their role in the pathophysiology of listeriosis.
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