Journal
ANNUAL REVIEW OF BIOCHEMISTRY
Volume 73, Issue -, Pages 539-557Publisher
ANNUAL REVIEWS
DOI: 10.1146/annurev.biochem.73.011303.074048
Keywords
SRP; signal sequence; SRP54; SRP19; SRP receptor; SRP RNA
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Funding
- NIGMS NIH HHS [GM 22778] Funding Source: Medline
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The signal recognition particle (SRP) directs integral membrane and secretory proteins to the cellular protein translocation machinery during translation. The SRP is an evolutionarily conserved RNA-protein complex whose activities are regulated by GTP hydrolysis. Recent structural investigations of SRP functional domains and interactions provide new insights into the mechanisms of SRP activity in all cells, leading toward a comprehensive understanding of protein trafficking by this elegant pathway.
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