Journal
JOURNAL OF ENDOTOXIN RESEARCH
Volume 10, Issue 6, Pages 413-418Publisher
MANEY PUBLISHING
DOI: 10.1179/096805104225006273
Keywords
cellular activation; lipopolysaccharide; inflammatory mediators
Categories
Funding
- NIAID NIH HHS [R01AI39576, R01AI31628, R01AI38515] Funding Source: Medline
- NIDDK NIH HHS [DK 32520] Funding Source: Medline
- NIGMS NIH HHS [R01GM54060] Funding Source: Medline
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R01AI039576, R01AI031628] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [P30DK032520] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM054060] Funding Source: NIH RePORTER
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Members of the Toll-like receptor (TLR) family have been shown to be important in the activation of cells by a variety of microbial ligands. TLRs are thought to mediate the 'recognition event' that follows an encounter between a mammalian cell and a microbial agent. In the case of the response to bacterial lipopolysaccharide (LPS), it is clear that the ability of these cell surface proteins to initiate the events necessary for activation of cells to produce cytokines is dependent upon 'accessory proteins' such as the pattern recognition protein CD14 and the lipopolysaccharide binding protein (LBP). While the role of these proteins in the LPS-specific response is defined, their role in other TLR responses has not been defined, but it is important in understanding these events and, potentially, in designing new therapeutic strategies. Here we report on the role of these proteins in the response to yeast zymosan. The requirements for this response (which unlike the response to LPS is a response to a particulate antigen) and the role of other serum proteins are defined.
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