Journal
JOURNAL OF ENDOTOXIN RESEARCH
Volume 10, Issue 4, Pages 238-240Publisher
SAGE PUBLICATIONS LTD
DOI: 10.1179/096805104225005841
Keywords
TLR4 polymorphisms; Asp299Gly; Thr399Ile; Chinese population
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Funding
- FIC NIH HHS [TW00828] Funding Source: Medline
- NIOSH CDC HHS [R01OH02421] Funding Source: Medline
- NATIONAL INSTITUTE FOR OCCUPATIONAL SAFETY AND HEALTH [R01OH002421] Funding Source: NIH RePORTER
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Endotoxin is an important component of bio-aerosols that contribute to airway inflammation and airflow obstruction. Toll-like receptor 4 (TLR4) mediates the host response to bacterial lipopolysaccharide (LPS), and the Asp299Gly and Thr399Ile polymorphisms have been associated with the development of respiratory diseases. We hypothesized that TLR4 polymorphisms may be associated with a decline of lung function in cotton workers who were exposed continuously to endotoxin. We investigated these two polymorphisms in our 20-year longitudinal cohort of Han Chinese cotton and silk textile workers. The two polymorphisms were genotyped using TaqMan and PCR-restriction fragment length polymorphism methods. No homozygous or heterozygous variant genotypes of the Asp299Gly and Thr339Ile polymorphisms were detected in 491 samples of this population. Our results suggest that the TLR4 Asp299Gly and Thr339Ile polymorphisms are very rare in the Chinese population.
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