Journal
CATALYSIS LETTERS
Volume 148, Issue 11, Pages 3335-3341Publisher
SPRINGER
DOI: 10.1007/s10562-018-2551-9
Keywords
Hen egg white lysozyme; Enzymatic promiscuity; 3-Indolyl-3-hydroxy oxindole; Isatin; Indole
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Funding
- UGC-BSR fellowship
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A green synthesis of 3-indolyl-3-hydroxy oxindoles was reported using hen egg white lysozyme (HEWL) in an aqueous ethanol. The HEWL promotes this reaction efficiently from various isatins and indoles under mild reaction conditions with yields up to 98% bearing good adaptability to varied substrates in the reaction. This conversion has provided a new strategy to synthesize 3-indolyl-3-hydroxy oxindole derivatives employing biocatalytic promiscuity of less explored lysozyme. Based on the experimental studies, the plausible reaction mechanism is proposed. [GRAPHICS] .
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