Journal
NEUROSIGNALS
Volume 13, Issue 3, Pages 130-133Publisher
KARGER
DOI: 10.1159/000076566
Keywords
eye enucleation; lateral habenular nucleus; Japanese monkey; immunocytochemistry; c-Fos
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To elucidate the effect of traumatic stress on the lateral habenular nucleus, we investigated the time course of the expression of c-Fos protein in this nucleus of the Japanese monkey (Macaca fuscata) after enucleation of one eye using c-Fos protein immunocytochemistry. c-Fos protein-like immunoreactive neurons were significantly increased; the increase started 1 h after the enucleation and remained high for 3-9 h in the lateral habenular nucleus on both sides. These results suggest that the prolonged expression of c-Fos protein occurred in the lateral habenular nucleus after traumatic stress through multiple transsynaptic activations. Copyright (C) 2004 S. Karger AG, Basel.
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