Journal
ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY
Volume 20, Issue -, Pages 223-253Publisher
ANNUAL REVIEWS
DOI: 10.1146/annurev.cellbio.20.011303.132633
Keywords
chemotaxis; G protein; PI(3,4,5)P-3; PI3-kinase; PTEN
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Funding
- NIGMS NIH HHS [GM 34933, GM 28007, F32 GM 065644] Funding Source: Medline
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM034933, R37GM028007, R01GM028007, F32GM065644] Funding Source: NIH RePORTER
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Dictyostelium is an accessible organism for studies of signaling via chemoattractant receptors. Chemoattractant-mediated signaling events and components are reviewed and presented as a series of connected modules, including excitation, inhibition, G protein-independent responses, early gene expression, inositol lipids, PH domain-containing proteins, cyclic AMP signaling, polarization acquisition, actin polymerization, and cortical myosin. The network incorporates information from biochemical, genetic, and cell biological experiments carried out on living cells. The modules and connections represent current understanding, and future information is expected to modify and build upon this structure.
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