Journal
CATALYSIS LETTERS
Volume 142, Issue 12, Pages 1505-1511Publisher
SPRINGER
DOI: 10.1007/s10562-012-0873-6
Keywords
Polyvinylsulfonic acid; Bronsted acid; Biginelli reaction; 3,4-Dihydropyrimidin-2(1H)-one
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A facile and environmentally benign protocol has been developed for the one-pot three-component synthesis of 3,4-dihydropyrimidin-2(1H)-ones/thiones from the cyclocondensation reaction of aldehyde, ethyl acetoacetate (beta-dicarbonyl compound) and urea or thiourea using polyvinylsulfonic acid as a reusable homogeneous Bronsted acid- and metal-free organocatalyst in water and ethanol. This new protocol has the advantages of easy availability, stability, reusability and eco-friendly of the catalyst, high to excellent yields, simple experimental and work-up procedure.
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