Journal
EXERCISE AND SPORT SCIENCES REVIEWS
Volume 32, Issue 1, Pages 36-40Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/00003677-200401000-00008
Keywords
aging; skeletal muscle; excitation-contraction coupling; denervation
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Funding
- NIA NIH HHS [AG18755, AG13934, AG15820] Funding Source: Medline
- NATIONAL INSTITUTE ON AGING [R01AG015820, R01AG018755, R01AG013934, R29AG013934] Funding Source: NIH RePORTER
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Excitation-contraction (EC) uncoupling is a major cause of decreased muscle force generating capacity (specific force). However, the underlying mechanisms of EC uncoupling in muscle from aging mammals have not been characterized. We propose that impaired motor neuron function with aging leading to muscle denervation, a process probably initiated earlier than detected by in vitro morphologic techniques, results in EC uncoupling.
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