Journal
EXERCISE AND SPORT SCIENCES REVIEWS
Volume 32, Issue 1, Pages 14-18Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/00003677-200401000-00004
Keywords
free radicals; gene expression; antioxidants; training; oxidant homeostasis
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Contracting skeletal muscle generates reactive oxygen and nitrogen species (ROS) that can induce changes in gene expression or cell damage depending upon the pattern of production and the endogenous protective systems. The hypothesis is presented that skeletal muscle uses contraction-induced ROS as signals to induce adaptive responses including maintenance of oxidant homeostasis and prevention of oxidative damage.
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