Journal
BMC NEUROLOGY
Volume 4, Issue -, Pages -Publisher
BMC
DOI: 10.1186/1471-2377-4-2
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Funding
- Research into Ageing
- UK Community Fund
- Salford Royal Hospitals NHS Trust Research and Development Directorate
- North Manchester Healthcare NHS Trust
- Salford Royal Hospitals NHS Trust
- NIH [NS26945, NS38710]
- National Institute of Neurological Disorders and Stroke
- Medical Research Council
- University of Manchester, UK
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [R01NS038710, R37NS038710, R01NS026945, Z01NS002924] Funding Source: NIH RePORTER
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Background: Cerebral ischaemia initiates an inflammatory response in the brain and periphery. We assessed the relationship between peak values of plasma interleukin-6 (IL-6) in the first week after ischaemic stroke, with measures of stroke severity and outcome. Methods: Thirty-seven patients with ischaemic stroke were prospectively recruited. Plasma IL-6, and other markers of peripheral inflammation, were measured at pre-determined timepoints in the first week after stroke onset. Primary analyses were the association between peak plasma IL-6 concentration with both modified Rankin score (mRS) at 3 months and computed tomography (CT) brain infarct volume. Results: Peak plasma IL-6 concentration correlated significantly (p < 0.001) with CT brain infarct volume (r = 0.75) and mRS at 3 months (r = 0.72). It correlated similarly with clinical outcome at 12 months or stroke severity. Strong associations were also noted between either peak plasma C-reactive protein (CRP) concentration or white blood cell (WBC) count, and all outcome measures. Conclusions: These data provide evidence that the magnitude of the peripheral inflammatory response is related to the severity of acute ischaemic stroke, and clinical outcome.
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