Journal
ANNUAL REVIEW OF PHYSIOLOGY
Volume 66, Issue -, Pages 131-159Publisher
ANNUAL REVIEWS
DOI: 10.1146/annurev.physiol.66.041002.142720
Keywords
metabolism; oxygen-sensitive K+ channels; BKCa channels
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Potassium (K+) channels exist in all three domains of organisms: eubacteria, archaebacteria, and eukaryotes. In higher animals, these membrane proteins participate in a multitude of critical physiological processes, including food and fluid intake, locomotion, stress response, and cognitive functions. Metabolic regulatory factors such as O-2, CO2/pH, redox equivalents, glucose/ATP/ADP, hormones, eicosanoids, cell volume, and electrolytes regulate a diverse group of K+ channels to maintain homeostasis.
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